Pragmatic Phase III Randomized Trial of Proton versus Photon Therapy for Patients with Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial Purpose To compare 2 types of standard care radiation treatment: photon and proton, to find out which type is best for treating non-metastatic breast cancer. Criteria Females or males diagnosed with invasive mammary carcinoma (ductal, lobular, or other) of the breast who have undergone either mastectomy or lumpectomy with any type of axillary surgery or axillary sampling Patients who have undergone any type of reconstruction are allowed Bilateral breast cancer is permitted Patients proceeding with breast/chest wall & nodal radiation therapy including internal mammary node treatment Age ≥ 21 years You Cannot: Have cancer anywhere else Have any prior radiation treatment for current breast cancer Details The total duration of this study is up to 10 years. The study consists of 3 periods: Pre-Radiation Treatment Period- within 30 days prior to radiation treatment starting Radiation Treatment Period- Daily (Monday-Friday) for approximately 5 to 7 weeks Follow Up Period- At 1 month, 6 months, & yearly from end of radiation treatment. Interested in more information on this clinical research study? Contact WK Cancer Center Clinical Research Department at 318-212-8671 Interested in more information? Contact Us: Radiation Oncology Services IRB: Willis-Knighton IRB Number: 16.0001 Trial Type: NA Sponsor: University of Pennsylvania